FIGURE 1.

Summary of the 53 new drugs under investigation for the treatment of ALS classified by their mechanism of action and included in a concentric circle. The outer ring indicates six drugs in phase 1, the middle ring indicates 31 drugs in phase 2, and the inner ring indicates 16 drugs in phase 3. Each color indicates a mechanism (anti-apoptotic, anti-inflammatory, anti-excitotoxicity, regulation of ISR, neurotrophic factors and neuroprotection, anti-aggregation, gene therapy and other mechanisms). The names of drugs according to different mechanisms are listed in the blank. Green words indicate drugs whose trial succeeded, black words indicate that the trial was ongoing, and words with strikethroughs indicate that the trial failed. Each dot represents a drug. White dots are drugs whose trials are ongoing, black dots are drugs whose trials failed, and green dots are drugs whose trials have positive results.