Figure 4.

Represents the protein expression of TNF-α (A) and NF-κB (B). Compound Ic revamps the release of inflammatory mediators, expressed by ELISA. The data are expressed as Mean ± SEM. n = 6/group. Symbol *** or ### shows significant difference at P<0.001, while * and ** show significant differences at P<0.05 and P<0.01, respectively. The symbol * represents the significant difference relative to the control group and the symbol # shows the significant difference relative to the disease group