Table 3.

Effects of biological sex in adoptive transfer EAE.

Donor cells	Recipients	Effect	Interpretation	References
MBP reactive T cells from female or male SJL mice	SJL mice of both sexes	Disease more severe in females	Sex of recipient determines the difference	(52)
				(52)
PLP139-151 reactive cells from male and female SJL mice	Female SJL mice	Disease more severe after transfer of female cells	Severity of EAE is related to the sex of the donor cells	(74)
MOG35-55 reactive Th17 cells from 1C6 TCR transgenic mice (NOD background) of both sexes	Female or male NOD.scid mice	Male Th17 cells caused greater disease than female cells in both female and male recipients	Sex of the donor determines the difference. Male Th17 cells have a greater intrinsic pathogenic capacity than female Th17 cells.	(75)
ACA83-95 reactive T cells from female or male SJL mice	SJL mice of both sexes	No difference in disease between males and females following transfer of female cells. No disease in female recipients and low incidence and severity of disease in males following transfer of male cells.	Disease-inducing ability of T cells is influenced by the sex of both the donor and recipient.	(66)
MOG92-106-specific T cells from female or male TCR1640 TCR transgenic mice (on SJL/J background)	SJL/J mice of both sexes	Relapsing-remitting disease course with increased clustering of Foxp3+ cells during remission in both males and females following transfer of female cells. Progressive disease course without recovery and more Th1 than Th17 lymphocytes in CNS during chronic phase in both males and females following transfer of male cells.	Disease course is dependent on the sex of the donor.	(73)