Table 1.
A summary of miRNAs’ expression levels of NEC in different studies.
| Study | miRNA name | Expression level | N (control) | N (NEC) | Detection method | Target gene | Sample source | Reference |
|---|---|---|---|---|---|---|---|---|
| Yin et al. 2019 | miR-124 | ↑ | / | / | qRT-PCR | ROCK1 | Rat NEC model tissue | (32) |
| Sun et al. 2020 | let-7d-5p | ↓ | 40 | 28 | qRT-PCR | LGALS3 | Rat NEC model tissue | (33) |
| Chen et al. 2020 | miR-141-3p | ↓ | / | 8 | qRT-PCR | MNX1 | Rat NEC model tissue | (34) |
| Xia et al. 2021 | miR-222 | ↑ | 12 | 12 | qRT-PCR | C-KIT | Rat NEC model tissue | (35) |
| Wu et al. 2019 | miR-431 | ↑ | 10 | 10 | qRT-PCR | FOXA1 | NEC human tissue | (30) |
| Chen* et al. 2020 | miR-146a-5p | ↑ | 22 | 17 | qRT-PCR | ND | NEC human tissue | (36) |
| Wu et al. 2021 | miR-223 | ↑ | 10 | 10 | qRT-PCR | NFIA | NEC human tissue | (37) |
| Li et al. 2020 | miR-141-3p | ↓ | 6 | 6 | qRT-PCR | RIPK1 | NEC human serum sample | (31) |
| Ng et al. 2020 | miR-223 | ↑ | 194 | 24 | qRT-PCR | ND | NEC human stool sample | (38) |
| miR-451a | ↑ | CLDN8 | ||||||
| Ng et al. 2019 | miR-1290 | ↑ | 265 | 36 | qRT-PCR | ND | NEC human plasma sample | (29) |
| miR-1246 | ↑ | FOXA1 | ||||||
| miR-375 | ↑ | ND | ||||||
| Galley et al. 2021 | miR-376a | ↓ | 12 | 14 | Sequencing analysis | ND | NEC human urine sample/Rat NEC model tissue | (10) |
| miR-518a-3p | ↓ | ND | ||||||
| miR-604 | ↓ | ND | ||||||
| Yu et al. 2020 | miR-27a-5p | ↑ | 3 | 3 | Sequencing analysis/qRT-PCR | ND | NEC human tissue/Rat NEC model tissue | (7) |
| miR-187-3p | ↓ | ND | ||||||
| miR-219-1-3p | ↑ | ND | ||||||
| miR-452-5p | ↑ | ND | ||||||
| Zhu et al. 2021 | miR-34a | ↑ | 30 | 30 | qRT-PCR | SIRT1 | NEC human serum sample/Rat NEC model tissue | (39) |
↑, significantly upregulated miRNAs in NEC; ↓, significantly downregulated miRNAs in NEC.
*
indicates not the same person; qRT-PCR, quantitative real-time PCR; ND, not determined.