Table 2.
miRNAs levels as biomarkers for diagnosis of NEC patients in different studies.
| miRNA name | Sample type | Disease cohort | Association | Expression states | Sensitivity | Specificity | AUC (95% CI) | DOR (95% CI) | Reference |
|---|---|---|---|---|---|---|---|---|---|
| miR-233 | Stool sample | 24 NEC vs. 194 non-NEC infants | Diagnosis of NEC | ↑ | 0.75 | 0.62 | 0.663 (0.546–0.779) | 4.84 | (38) |
| miR-451 | Stool sample | ↑ | 0.75 | 0.6 | 0.680 (0.580–0.779) | 4.46 | |||
| miR-1290 | Plasm sample | 36 NEC vs. 265 non-NEC infants | ↑ | 0.83 | 0.92 | 0.917 (0.866–0.968) | 61.25 (22.81–164.50) | (29) | |
| miR-1246 | Plasm sample | ↑ | 0.72 | 0.94 | 0.843 (0.766–0.921) | 37.14 (12.30–112.20) | |||
| miR-375 | Plasm sample | ↑ | 0.81 | 0.85 | 0.869 (0.796–0.942) | 43.33 (17.68–106.19) | |||
| miR-376a | Urine sample | 9 surgical NEC vs. 4 non-NEC sepsis | ↑ | / | / | / | / | (10) | |
| miR-518-3p | Urine sample | 7 surgical NEC vs. 4 non-NEC sepsis | ↑ | / | / | / | / | ||
| miR-604 | Urine sample | 14 NEC vs. 8 control | ↑ | / | / | / | / |
AUC, Area Under Curve; DOR, diagnostic odds ratio; 95% CI, 95% confidence interval.