Table 3.
Summary of potential therapeutic miRNAs in NEC.
| miRNA name | Targets | Functions | Therapy | Reference |
|---|---|---|---|---|
| miR-124 | RCOK1 | Involves in apoptosis and inflammatory cell infiltration | Antagonism | (32) |
| Let-7d-5p | / | Involves in apoptosis and inflammatory factors expression | Mimicry | (33) |
| miR-431 | FOXA1 | Involves in inflammatory response in NEC tissues | Antagonism | (30) |
| miR-141-3p | RIPK1 | Involves in inflammation and necrosis | Mimicry | (31) |
| miR-141-3p | MNX1 | Involves in inflammatory factors expression | Mimicry | (34) |
| miR-146a-5p | / | Involves in NEC rat survival, weight loss and intestinal injury | Mimicry | (36) |
| miR-223 | NFIA | Involves in inflammation and cellular functions | Antagonism | (38) |
| miR-222 | C-KIT | Involves in inflammation | Antagonism | (37) |
| miR-34a | SIRT1 | Involves in intestinal villi injury | Antagonism | (39) |