Table 5. Factors related to irAEs.
| Factors | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Smoking index | 1.000 (0.999–1.001) | 0.850 | |||
| ECOG PS | 1.396 (0.589–3.311) | 0.449 | |||
| Histology | |||||
| Adenocarcinoma | 1 | 0.478 | |||
| Squamous cell carcinoma | 1.889 (0.456–7.821) | 0.380 | |||
| Other | 1.149 (0.262–5.034) | 0.853 | |||
| TNM stage | 1.326 (0.527–3.335) | 0.549 | |||
| Anti-COPD drugs | 1.806 (0.545–5.983) | 0.334 | |||
| GOLD degree | 2.063 (1.286–3.309) | 0.003 | 1.774 (1.035–3.039) | 0.037 | |
| Cytokines | |||||
| IL-6 | 1.032 (1.008–1.056) | 0.007 | 1.013 (0.989–1.038) | 0.275 | |
| IL-8 | 1.036 (1.005–1.067) | 0.022 | |||
| IL-10 | 1.349 (1.091–1.668) | 0.006 | 1.219 (0.976–1.521) | 0.080 | |
| KL-6 | 1.001 (1.000–1.002) | 0.060 | |||
irAEs, immune-related adverse events; ECOG, Eastern Cooperative Oncology Group; PS, physical state; TNM, tumor node metastasis; COPD, chronic obstructive pulmonary disease; GOLD, Global Initiative for Chronic Obstructive Lung Disease; IL-6, interleukin-6; IL-8, interleukin-8; IL-10, interleukin-10; KL-6, Krebs Von den Lungen-6; HR, hazard ratio; CI, confidence interval.