4.

miR-607靶向TRPC5抑制Akt通路激活

miR-607 inhibits Akt pathway activation through targeting TRPC5. A: miR-607 was predicted to bind to TRPC5 mRNA 3'-UTR region by bioinformatics analysis. B: Overexpression of miR-607 inhibits luciferase activity of wild-type (Wt) but not mutant-type (Mut) 3'-UTR vectors of TRPC5 in HCC cells. C: Overexpression of miR-607 decreases TRPC5 mRNA expression in HCC cells. D, E: Total expressions of TRPC5, CCND1, MMP2 and phosphorylated Akt are decreased in Huh7 (D) and HCCLM3 (E) cells. ^*P < 0.05 vs miR-ctrl group.