Table 3.
Effects of D-allulose administration on fetal skeletal alterationsa.
| Examination Indicators | Dose Groups (mg/kg bw) |
|||
|---|---|---|---|---|
| 0 | 1250 | 2500 | 5000 | |
| Skull | ||||
| Skull osteolysis | 0/0b) | 0/0 | 0/0 | 0/0 |
| Interparietal bone imperfect | 0/0 | 0/0 | 0/0 | 0/0 |
| Interparietal bone deficiency | 0/0 | 0/0 | 0/0 | 0/0 |
| Occipital bone imperfect | 0/0 | 0/0 | 0/0 | 0/0 |
| Occipital bone deficiency | 0/0 | 0/0 | 0/0 | 0/0 |
| Sternum | ||||
| Sternum deficiency | 1/1 | 0/0 | 2/2 | 2/2 |
| Sternum fusion | 0/0 | 0/0 | 0/0 | 0/0 |
| Rib | ||||
| Wavy rib | 0/0 | 0/0 | 0/0 | 0/0 |
| Shortened rib | 0/0 | 0/0 | 0/0 | 0/0 |
| Rib fracture | 0/0 | 0/0 | 0/0 | 0/0 |
| Absence of rib | 0/0 | 0/0 | 0/0 | 0/0 |
| Extra rib | 0/0 | 0/0 | 0/0 | 0/0 |
| Phalanges | ||||
| Oligodactyly | 0/0 | 0/0 | 0/0 | 0/0 |
No statistically significant differences were noted among the groups when analyzed by the Anova or Dunnett test.
a
Skeletal alterations were examined on 120, 150, 129, and 120 fetuses from 17, 20, 17, and 18 litters of the vehicle control, 1250, 2500, and 5000 mg/kg bw dose groups, respectively.
b
) Number of fetuses with the alteration /number of litters with the alteration.