Fig. 1.

MPP⁺ induced cytotoxicity in HDNPCs. Differentiated HDNPCs were exposed to MPP⁺ [0–10 mM] for 24 h. After treatment LDH release (A), metabolic activity (B), mitochondrial function (C) and the number of live/dead cells (D) were analyzed. Each value represents the mean ± SEM of three independent experiments. * p < 0.05 and **** p < 0.0001 vs. control. In the micrographs of differentiated HDNPCs exposed to MPP⁺, mitochondria were stained in red for MitoTracker panel. FITC-green represents live cells and TRITC-red represents dead cells in Live/Dead panel. Blue stain represents nuclei in both panels.(For interpretation of the references to colour in this figure, the reader is referred to the web version of this article.)