Table 1.
Hematological parameters data by dosage group and sex in subchronic toxicity study.
| Hemograms | Sex | Experimental groups |
|||
|---|---|---|---|---|---|
| Control | 559.36 mg/kg | 1118.72 mg/kg | 2237.44 mg/kg | ||
| WBC (x103/µL) | F | 6.38 + 1.41 | 7.93 + 1.04 | 7.91 + 1.04 | 7.80 + 0.47 |
| M | 7.11 + 0.66 | 6.55 + 0.80 | 7.10 + 0.65 | 7.86 + 0.82 | |
| RBC (x106/µL) | F | 7.81 + 0.09 | 8.03 + 0.42 | 8.02 + 0.61 | 7.77 + 0.31 |
| M* | 8.79 + 0.40 | 9.04 + 0.17 | 8.78 + 0.39 | 8.65 + 0.17 | |
| PLT (x103/µL) | F | 988.00 + 100.95 | 952.20 + 94.00 | 957.20 + 48.70 | 961.60 + 32.70 |
| M | 1026.20 + 4.59 | 975.40 + 38.10 | 1025.80 + 44.27 | 956.00 + 64.34 | |
| HGB (g/dL) | F | 15.09 + 0.13 | 15.86 + 0.52 | 15.45 + 0.77 | 15.46 + 0.59 |
| M* | 16.59 + 0.78 | 16.62 + 0.43 | 16.58 + 0.77 | 16.25 + 0.34 | |
| HCT (%) | F | 43.38 + 0.33 | 45.53 + 1.61 | 45.52 + 1.61 | 44.55 + 1.58 |
| M* | 46.23 + 1.66 | 46.38 + 2.25 | 45.22 + 1.35 | 46.23 + 0.72 | |
| MCH (pg) | F* | 19.35 + 0.11 | 19.30 + 0.08 | 19.29 + 0.08 | 19.31 + 0.70 |
| M | 18.90 + 0.08 | 18.81 + 0.150 | 18.89 + 0.08 | 18.78 + 0.12 | |
| MCHC (g/dL) | F | 34.80 + 0.21 | 34.22 + 0.64 | 34.20 + 0.64 | 34.68 + 0.18 |
| M* | 35.88 + 0.37 | 35.38 + 0.42 | 35.88 + 0.37 | 35.34 + 0.52 | |
| MCV (fL) | F* | 55.57 + 0.65 | 56.42 + 1.30 | 56.41 + 1.30 | 57.43 + 1.30 |
| M | 52.58 + 0.50 | 53.09 + 0.30 | 52.57 + 0.50 | 53.10 + 0.97 | |
| LYMP (%) | F* | 5.22 + 1.10 | 6.45 + 1.72 | 6.45 + 1.73 | 6.75 + 0.51 |
| M | 4.93 + 0.30 | 4.41 + 1.04 | 4.94 + 0.31 | 5.11 + 1.30 | |
| NEUT (%) | F | 0.85 + 0.22 | 1.30 + 0.10 | 1.32 + 0.12 | 1.13 + 0.57 |
| M* | 1.95 + 0.39 | 1.48 + 0.52 | 1.76 + 0.30 | 1.61 + 0.68 | |
| MONO (%) | F* | 0.29 + 0.07 | 0.30 + 0.05 | 0.31 + 0.07 | 0.24 + 0.04 |
| M | 0.14 + 0.07 | 0.17 + 0.15 | 0.14 + 0.07 | 0.12 + 0.07 | |
| EOSI (%) | F | 0.08 + 0.02 | 0.07 + 0.01 | 0.07 + 0.01 | 0.08 + 0.01 |
| M | 0.08 + 0.00 | 0.08 + 0.03 | 0.08 + 0.00 | 0.08 + 0.02 | |
| BASO (%) | F* | 0.02 + 0.01 | 0.03 + 0.01 | 0.03 + 0.01 | 0.02 + 0.02 |
| M | 0.02 + 0.01 | 0.01 + 0.00 | 0.01 + 0.01 | 0.02 + 0.01 | |
Values are presented as M + SD/E; One/two -way ANOVA followed by a Dennett’s post hoc test; P < 0.05, was considered statistically significant; *Significant p-value, between male and female groups; n = 5 animals/sex/group.