Fig. 8.

Gene set based BMD_T values identified for paired RNA-Seq FROZ and FFPE and paired TempO-Seq FROZ and FFPE liver tissue samples. A. Accumulation plots of lowest median BMD_T derived from mapping genes/probes to signaling pathways in Reactome. Enrichment based on at least 3 or more genes and a Fisher’s Exact Test, two-tailed, p-value < 0.05. B. Boxplots show distribution in pathway level BMD_T results across sample types and methods. Abbreviations: FFPE-formalin-fixed paraffin-embedded, FROZ-frozen, RNA-Seq- RNA-Sequencing, BMD_T - transcriptomic benchmark dose.