Table 2.
Concentration-dependent effects of eugenol on ADP-induced (10 µM) human platelet total and biphasic aggregation ex vivo.
| Eugenol [µM] | N | Eugenol+ADP |
Normalized to 100% aggregation |
|||
|---|---|---|---|---|---|---|
| Total (%) | Phase 1 (%) | Phase 2 (%) | Phase 1 (%) | Phase 2 (%) | ||
| 0; Control | 24 | 66 ± 4 | 41 ± 3 | 25 ± 3 | 62 ± 3 | 38 ± 3 |
| 10 | 9 | 49 ± 2 * | 38 ± 3 | 13 ± 4 * | 79 ± 4 * | 21 ± 4 * |
| 25 | 12 | 42 ± 3 * | 43 ± 2 | -1 ± 1 * | 99 ± 3 * | 1 ± 3 * |
| 100 | 17 | 41 ± 2 * | 43 ± 2 | -2 ± 1 * | 106 ± 3 * | -6 ± 3 * |
Data are mean ± SEM. Abbreviations: ADP, adenosine diphosphate; N, number of human subjects. Total aggregation = Phase 1 (%) + Phase 2 (%). *P < 0.05, One-Way ANOVA with repeated measures.