Table 1b.

Effect of orally administered Withaferin-A on RFT and LFT parameters in sub-acute toxicity.

Test	Unit	VC	10 mg/kg	70 mg/kg	500 mg/kg	VC Recovery	500 mg/kg Recovery
TP	g/dl	4.9 ± 0.3	5.1 ± 0.0	4.9 ± 0.5	4.8 ± 0.4	5.3 ± 0.1	5.5 ± 0.1
ALB	g/dl	1.6 ± 0.1	1.4 ± 0.0	1.5 ± 0.4	1.7 ± 0.1	1.2 ± 0.2	1.3 ± 0.3
ALP	U/L	145.3 ± 8.0	123.8 ± 3.7	138.2 ± 6.2	138.6 ± 11.5	121.6 ± 3.9	133.4 ± 4.5
TB	mg/dl	0.1 ± 0.0	0.2 ± 0.0	0.3 ± 0.0	0.1 ± 0.0	0.2 ± 0.0	0.2 ± 0.1
AST	U/L	185.5 ± 13.8	181.4 ± 5.2	169.8 ± 31.9	162.4 ± 19.0	158.0 ± 9.4	173.4 ± 5.1
ALT	U/L	48.8 ± 5.9	42.4 ± 2.0	43.8 ± 4.7	46.4 ± 1.4	41.0 ± 1.7	51.0 ± 6.6
BUN	mg/dl	46.5 ± 5.9	50.4 ± 2	55.2 ± 2.3	50.6 ± 5.7	49 ± 2.0	45.6 ± 5.2
URCA	mg/dl	2.0 ± 0.3	2.4 ± 0.2	1.8 ± 0.1	1.2 ± 0.2	1.9 ± 0.3	2.1 ± 0.4
CREA	mg/dl	0.4 ± 0.0	0.3 ± 0.0	0.4 ± 0.0	0.5 ± 0.0	0.3 ± 0.1	0.4 ± 0.1

All values are represented as Mean ± SEM. TP: total protein, ALB: albumin, ALP: alkaline phosphatase, TB: total bilirubin, AST: aspartate aminotransferase, ALT: alanine aminotransferase, BUN: blood urea nitrogen, URCA: uric acid, CREA: creatinine