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Summary of ivMN assay positive controls.
| Treatment Schedule | S9 Metabolic Activation | Positive Control | Aneugen / Clastogen | Concentration [µg/mL] |
|---|---|---|---|---|
| Schedule (i) | No activation | Mitomycin C (MMC) | clastogen | 2 |
| Schedule (i) | No activation | Colchicine | aneugen | 2 |
| Schedule (ii) | Rat liver | Cyclophosphamide (CP) | clastogen | 7.5 |
| Schedule (iii) | No activation | Mitomycin C (MMC) | clastogen | 0.5 |
| Schedule (iii) | No activation | Colchicine | aneugen | 0.5 |
