Table 3.
Coagulation values of rats following oral administration of GMI over 13-week period.
Male |
Female |
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0 mg GMI / kg bw | 50 mg GMI / kg bw | 75 mg GMI / kg bw | 100 mg GMI / kg bw | 0 mg GMI / kg bw | 50 mg GMI / kg bw | 75 mg GMI / kg bw | 100 mg GMI / kg bw | |||
Day 92 | APTT | seconds | 17.94 ± 1.84 | 18.24 ± 2.75 | 18.9 ± 1.54 | 18.01 ± 1.84 | 16.93 ± 2.26 | 17.67 ± 2.68 | 17.38 ± 3.32 | 16.47 ± 2.06 |
PT | seconds | 22.47 ± 0.94 | 22.5 ± 2.09 | 23.15 ± 1.48 | 23.41 ± 1.01 | 23.71 ± 1.14 | 24.81 ± 1.01 | 23.94 ± 1.77 | 24.81 ± 1.38 | |
Day 120 | APTT | seconds | 16.72 ± 0.83 | 15.32 ± 1.45 | 16.54 ± 1.71 | 16.5 ± 3 | ||||
PT | seconds | 22.2 ± 0.89 | 21.96 ± 1.5 | 23.44 ± 1.07 | 24.04 ± 0.92 |
Note: Activated partial thromboplastin Time (APTT); Prothrombin time (PT)