Table 4.
Relative organ weights (%Brain weight) of rats following oral administration of GMI over 13-week period.
| Dose level | 0 mg GMI / kg bw | 50 mg GMI / kg bw | 75 mg GMI / kg bw | 100 mg GMI / kg bw | |||
|---|---|---|---|---|---|---|---|
| Gender | Male | ||||||
| Day 92 | Adrenals | %BrainWt | Percentage | 2.802 ± 0.448 | 3.102 ± 0.399 | 2.633 ± 0.382 | 2.969 ± 0.34 |
| Heart | %BrainWt | Percentage | 84.234 ± 41.455 | 71.004 ± 6.342 | 73.881 ± 7.687 | 73.613 ± 8.108 | |
| Kidneys | %BrainWt | Percentage | 161.574 ± 19.5 | 166.504 ± 17.517 | 160.051 ± 23.083 | 176.726 ± 21.629 | |
| Liver | %BrainWt | Percentage | 609.397 ± 117.226 | 615.078 ± 53.411 | 599.924 ± 61.646 | 601.618 ± 88.67 | |
| Spleen | %BrainWt | Percentage | 34.3 ± 5.316 | 34.913 ± 3.594 | 33 ± 5.014 | 32.031 ± 2.53 | |
| Thymus | %BrainWt | Percentage | 14.187 ± 4.229 | 16.929 ± 4.035 | 12.381 ± 2.455 | 13.26 ± 1.527 | |
| Thyroids | %BrainWt | Percentage | 1.755 ± 0.448 | 1.464 ± 0.45 | 1.532 ± 0.415 | 1.531 ± 0.36 | |
| Testes | %BrainWt | Percentage | 211.199 ± 33.874 | 220.712 ± 13.608 | 209.282 ± 18.723 | 230.127 ± 17.027 | |
| Gender | Female | ||||||
| Day 92 | Adrenals | %BrainWt | Percentage | 3.854 ± 0.875 | 3.758 ± 0.304 | 3.5 ± 0.655 | 3.668 ± 1.104 |
| Heart | %BrainWt | Percentage | 55.039 ± 6.693 | 52.471 ± 6.626 | 49.894 ± 7.973 | 49.457 ± 4.227 | |
| Kidneys | %BrainWt | Percentage | 104.083 ± 9.997 | 100.058 ± 8.068 | 103.153 ± 7.087 | 101.59 ± 8.928 | |
| Liver | %BrainWt | Percentage | 399.417 ± 43.746 | 365.135 ± 32.308 | 384.751 ± 42.618 | 382.148 ± 33.334 | |
| Spleen | %BrainWt | Percentage | 26.86 ± 4.482 | 24.153 ± 4.302 | 27.305 ± 5.09 | 26.497 ± 3.743 | |
| Thymus | %BrainWt | Percentage | 12.717 ± 2.059 | 12.353 ± 2.158 | 13.133 ± 2.739 | 12.785 ± 2.978 | |
| Thyroids | %BrainWt | Percentage | 1.332 ± 0.188 | 1.103 ± 0.235 | 1.136 ± 0.272 | 1.146 ± 0.185 | |
| Uterus | %BrainWt | Percentage | 36.496 ± 11.512 | 33.777 ± 6.261 | 36.596 ± 6.225 | 37.051 ± 15.019 | |
| Ovaries | %BrainWt | Percentage | 5.608 ± 0.691 | 4.242 ± 1.089* | 4.184 ± 0.938** | 5.093 ± 1.047 | |
| Dose level | 0 mg GMI / kg bw | 100 mg GMI / kg bw | 0 mg GMI / kg bw | 100 mg GMI / kg bw | |||
| Gender | Male | Female | |||||
| Day 120 | Adrenals | %BrainWt | Percentage | 2.95 ± 0.419 | 2.83 ± 0.251 | 4.146 ± 0.783 | 3.704 ± 0.577 |
| Heart | %BrainWt | Percentage | 77.234 ± 5.609 | 78.956 ± 11.678 | 52.856 ± 8.456 | 51.666 ± 6.567 | |
| Kidneys | %BrainWt | Percentage | 163.452 ± 23.718 | 172.44 ± 19.584 | 111.854 ± 9.058 | 104.106 ± 6.808 | |
| Liver | %BrainWt | Percentage | 712.462 ± 65.724 | 762.856 ± 127.778 | 453.45 ± 81.526 | 409.356 ± 54.828 | |
| Spleen | %BrainWt | Percentage | 39.834 ± 4.532 | 44.136 ± 6.435 | 25.066 ± 2.663 | 26.918 ± 5.063 | |
| Thymus | %BrainWt | Percentage | 14.014 ± 0.975 | 12.486 ± 2.093 | 9.542 ± 3.042 | 11.506 ± 3.321 | |
| Thyroids | %BrainWt | Percentage | 1.654 ± 0.173 | 1.632 ± 0.445 | 1.154 ± 0.164 | 1.214 ± 0.28 | |
| Testes | %BrainWt | Percentage | 215.51 ± 19.833 | 233.476 ± 13.934 | |||
| Uterus | %BrainWt | Percentage | 39.75 ± 4.209 | 33.686 ± 8.075 | |||
| Ovaries | %BrainWt | Percentage | 4.844 ± 1.758 | 5.358 ± 1.671 | |||
Note: Weight (Wt); Body weight (bw); *p < 0.05, significantly different from controls; ** p < 0.01, significantly different from controls.