Table 5.
Relative organ weights (%Body weight) of rats following oral administration of GMI over 13-week period.
| Dose level | 0 mg GMI / kg bw | 50 mg GMI / kg bw | 75 mg GMI / kg bw | 100 mg GMI / kg bw | |||
|---|---|---|---|---|---|---|---|
| Gender | Male | ||||||
| Day 92 | Adrenals | % BW | Percentage | 0.0126 ± 0.0025 | 0.0134 ± 0.0019 | 0.0118 ± 0.0014 | 0.0131 ± 0.0018 |
| Brain | % BW | Percentage | 0.4527 ± 0.0647 | 0.435 ± 0.0294 | 0.4515 ± 0.0357 | 0.4482 ± 0.0468 | |
| Heart | % BW | Percentage | 0.3889 ± 0.2455 | 0.3075 ± 0.0168 | 0.3325 ± 0.0339 | 0.328 ± 0.0304 | |
| Kidneys | % BW | Percentage | 0.7215 ± 0.0475 | 0.7239 ± 0.0873 | 0.7225 ± 0.1185 | 0.7857 ± 0.0657 | |
| Liver | % BW | Percentage | 2.6952 ± 0.1827 | 2.6625 ± 0.1163 | 2.69 ± 0.1616 | 2.6623 ± 0.1501 | |
| Spleen | % BW | Percentage | 0.1533 ± 0.0186 | 0.1515 ± 0.0142 | 0.148 ± 0.0174 | 0.143 ± 0.012 | |
| Thymus | % BW | Percentage | 0.0647 ± 0.0257 | 0.0733 ± 0.0172 | 0.0557 ± 0.0109 | 0.0592 ± 0.0068 | |
| Thyroids | % BW | Percentage | 0.0079 ± 0.0024 | 0.0062 ± 0.002 | 0.0069 ± 0.002 | 0.0069 ± 0.0019 | |
| Testes | % BW | Percentage | 0.9471 ± 0.1456 | 0.9596 ± 0.0854 | 0.9452 ± 0.1199 | 1.0301 ± 0.1126 | |
| Gender | Female | ||||||
| Day 92 | Adrenals | % BW | Percentage | 0.0262 ± 0.0062 | 0.0274 ± 0.0035 | 0.0256 ± 0.006 | 0.0262 ± 0.0077 |
| Brain | % BW | Percentage | 0.6889 ± 0.0696 | 0.7282 ± 0.065 | 0.7235 ± 0.0782 | 0.7129 ± 0.0516 | |
| Heart | % BW | Percentage | 0.3758 ± 0.0298 | 0.379 ± 0.0293 | 0.3563 ± 0.0328 | 0.3514 ± 0.0258 | |
| Kidneys | % BW | Percentage | 0.7133 ± 0.0646 | 0.7254 ± 0.0489 | 0.7442 ± 0.0739 | 0.7246 ± 0.0846 | |
| Liver | % BW | Percentage | 2.728 ± 0.152 | 2.6472 ± 0.2035 | 2.7723 ± 0.3433 | 2.7142 ± 0.1944 | |
| Spleen | % BW | Percentage | 0.1831 ± 0.0223 | 0.1739 ± 0.0191 | 0.1966 ± 0.0393 | 0.1882 ± 0.0242 | |
| Thymus | % BW | Percentage | 0.0873 ± 0.0142 | 0.0893 ± 0.014 | 0.0931 ± 0.011 | 0.0904 ± 0.0177 | |
| Thyroids | % BW | Percentage | 0.0091 ± 0.0018 | 0.0079 ± 0.0014 | 0.0081 ± 0.002 | 0.0081 ± 0.0017 | |
| Uterus | % BW | Percentage | 0.2483 ± 0.0672 | 0.249 ± 0.0627 | 0.2641 ± 0.0477 | 0.2671 ± 0.1147 | |
| Ovaries | % BW | Percentage | 0.0389 ± 0.0069 | 0.0305 ± 0.007* | 0.0297 ± 0.0045* | 0.0361 ± 0.0073 | |
| Dose level | 0 mg GMI / kg bw | 100 mg GMI / kg bw | 0 mg GMI / kg bw | 100 mg GMI / kg bw | |||
| Gender | Male | Female | |||||
| Day 120 | Adrenals | % BW | Percentage | 0.0112 ± 0.0008 | 0.0102 ± 0.0011 | 0.0282 ± 0.0033 | 0.025 ± 0.0054 |
| Brain | % BW | Percentage | 0.395 ± 0.0408 | 0.3736 ± 0.0434 | 0.692 ± 0.094 | 0.6678 ± 0.068 | |
| Heart | % BW | Percentage | 0.3038 ± 0.0233 | 0.2914 ± 0.02 | 0.36 ± 0.0243 | 0.3416 ± 0.0134 | |
| Kidneys | % BW | Percentage | 0.6422 ± 0.0812 | 0.6394 ± 0.0507 | 0.7694 ± 0.0767 | 0.6936 ± 0.0605 | |
| Liver | % BW | Percentage | 2.7988 ± 0.2029 | 2.808 ± 0.2355 | 3.08 ± 0.2039 | 2.7142 ± 0.2752* | |
| Spleen | % BW | Percentage | 0.1574 ± 0.0254 | 0.1632 ± 0.0177 | 0.172 ± 0.0144 | 0.1802 ± 0.0429 | |
| Thymus | % BW | Percentage | 0.0554 ± 0.0063 | 0.047 ± 0.0113 | 0.0642 ± 0.0118 | 0.075 ± 0.0151 | |
| Thyroids | % BW | Percentage | 0.0064 ± 0.0005 | 0.006 ± 0.0014 | 0.008 ± 0.0016 | 0.0078 ± 0.0013 | |
| Testes | % BW | Percentage | 0.845 ± 0.0252 | 0.8704 ± 0.0973 | |||
| Uterus | % BW | Percentage | 0.2732 ± 0.0297 | 0.2226 ± 0.0453 | |||
| Ovaries | % BW | Percentage | 0.0326 ± 0.0103 | 0.0362 ± 0.0138 | |||
Note: Body weight (BW or bw); *p < 0.05, significantly different from controls.