Table 6.
External, visceral, skeletal, ossification examination of fetuses.
| Dose level |
|||||
|---|---|---|---|---|---|
| Parameters | Classification | 0 mg GMI /kg bw | 50 mg GMI /kg bw | 75 mg GMI /kg bw | 100 mg GMI /kg bw |
| No. of fetuses (litters) examined | 325(21) | 365(24) | 349(23) | 358(23) | |
| No. of fetuses (litters) with abnormalities | 2(2) | 3(2) | 2(2) | 0(0) | |
| % fetuses (litters) with abnormalities | 0.6%(9.5%) | 0.8%(8.3%) | 0.6%(8.7%) | 0.0%(0.0%) | |
| No. of fetuses (litters) with variations | 1(1) | 3(2) | 1(1) | 0(0) | |
| % fetuses (litters) with variations | 0.3%(4.8%) | 0.8%(8.3%) | 0.3%(4.3%) | 0.0%(0.0%) | |
| No. of fetuses (litters) with Malformations | 1(1) | 0(0) | 1(1) | 0(0) | |
| % fetuses (litters) with Malformations | 0.3%(4.8%) | 0.0%(0.0%) | 0.3%(4.3%) | 0.0%(0.0%) | |
| External abnormalities | |||||
| Trunk/head, subcutaneous hemorrhage | Variation | 1(1) | 3(2) | 1(1) | 0(0) |
| General, small | Malformation | 1(1) | 0(0) | 1(1) | 0(0) |
| No. of fetuses (litters) examined | 167(21) | 189(24) | 181(23) | 186(23) | |
| No. of fetuses (litters) with abnormalities | 9(7) | 8(5) | 9(6) | 10(7) | |
| % fetuses (litters) with abnormalities | 5.4% (33.3%) | 4.2% (20.8%) | 5.0% (26.1%) | 5.4% (30.4%) | |
| No. of fetuses (litters) with variations | 8(7) | 8(5) | 8(5) | 9(6) | |
| % fetuses (litters) with variations | 4.8% (33.3%) | 4.2% (20.8%) | 4.4% (21.7%) | 4.8% (26.1%) | |
| No. of fetuses (litters) with Malformations | 1(1) | 0(0) | 1(1) | 1(1) | |
| % fetuses (litters) with Malformations | 0.6% (4.8%) | 0.0% (0.0%) | 0.5% (4.3%) | 0.5%(4.3%) | |
| Visceral abnormalities | |||||
| Renal pelvic, dilated | Variation | 7(6) | 8(5) | 8(5) | 9(6) |
| Diaphragm, thin | Variation | 1(1) | 0(0) | 0(0) | 0(0) |
| Lung, abnormal lobation | Malformation | 1(1) | 0(0) | 0(0) | 1(1) |
| Lung, Lobe fused | Malformation | 0(0) | 0(0) | 1(1) | 0(0) |
| No. of fetuses (litters) examined | 158 (21) | 176(24) | 168(23) | 172(23) | |
| No. of fetuses (litters) with abnormalities | 23(13) | 23(10) | 21(11) | 24(15) | |
| % fetuses (litters) with abnormalities | 14.6%(61.9%) | 13.1%(41.7%) | 12.5%(47.8%) | 14.0%(65.2%) | |
| No. of fetuses (litters) with variations | 23(13) | 23(10) | 21(11) | 24(15) | |
| % fetuses (litters) with variations | 14.6%(61.9%) | 13.1%(41.7%) | 12.54%(47.8%) | 14.0%(65.2%) | |
| No. of fetuses (litters) with Malformations | 0(0) | 1(1) | 0(0) | 0(0) | |
| % fetuses (litters) with Malformations | 0.0%(0.0%) | 0.6%(4.2%) | 0.0%(0.0%) | 0.0%(0.0%) | |
| Skeletal abnormalities | |||||
| Interparietal, incomplete ossification | Variation | 0(0) | 1(1) | 0(0) | 0(0) |
| sternebrae,incomplete ossification | Variation | 0(0) | 0(0) | 3(2) | 3(3) |
| Sternebrae, unossified | Variation | 4(3) | 4(2) | 4(3) | 1(1) |
| costal cartillage, interrupted | Variation | 0(0) | 0(0) | 3(3) | 0(0) |
| Thoracic centrum, bipartite ossification | Variation | 19(10) | 19(9) | 15(9) | 20(13) |
| Lumbar arch, absent | Malformation | 0(0) | 1(1) | 0(0) | 0(0) |
| Litters examined | 21 | 24 | 23 | 23 | |
| Fetuses examined | 158 | 176 | 168 | 172 | |
| Vertebrae | |||||
| Cervical | Mean±SD | 7 ± 0 | 7 ± 0 | 7 ± 0 | 7 ± 0 |
| Thoracic | Mean±SD | 13 ± 0 | 13 ± 0 | 13 ± 0 | 13 ± 0 |
| Lumbar | Mean±SD | 6 ± 0 | 6 ± 0 | 6 ± 0 | 6 ± 0 |
| Sacral | Mean±SD | 4 ± 0 | 4 ± 0 | 4 ± 0 | 4 ± 0 |
| Caudal | Mean±SD | 5.6 ± 0.5 | 5.3 ± 0.6 | 5.4 ± 0.7 | 5.3 ± 0.5 |
| Ribs(Pairs) | Mean±SD | 13 ± 0 | 13 ± 0 | 13 ± 0 | 13 ± 0 |
| Sternum | Mean±SD | 6 ± 0.1 | 6 ± 0.1 | 6 ± 0 | 6 ± 0 |
| Metacarpal | Mean±SD | 4 ± 0 | 4 ± 0 | 4 ± 0 | 4 ± 0 |
| Metatarsal | Mean±SD | 4.6 ± 0.3 | 4.5 ± 0.3 | 4.5 ± 0.4 | 4.6 ± 0.3 |