Table 1.
List of functionally important synaptic proteins identified in our study showing significant dysregulation upon Pb2+ exposure.
| S. No. | Protein name | Function | Fold change | References |
|---|---|---|---|---|
| 1 | Synatotagmin 1 (SYT1) | Major synaptic vesicular protein that acts as a principal Ca2 + sensor | 0.61 | [33], [34] |
| 2 | Src substrate cortactin (CTTN) | Involved in receptor-mediated endocytosis via clathrin-coated pits | 2.27 | [35] |
| 3 | Nedd4 binding protein 3 (N4BP3) | Functions associated with axon and dendrite arborization during cranial nerve development | 2.3 | [36] |
| 4 | Acid sensing ion channel 2 (ASIC2) | A cation channel with high affinity to Na+ and permeable to Li+ and K+ | 2.68 | [37] |
| 5 | Synapsin-1 isoform a (SYN1) | A neuronal phosphor protein that regulates neurotransmitter release | 1.37 | [38] |
| 6 | Ca+2/calmodulin-dependent protein kinase II gamma (CAMK2G) Ca2+/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) |
Belong to the family of Ca2+/calmodulin-dependent protein kinase could play a crucial role in regulating synaptic transmission and LTP maintenance | 0.54 0.57 |
[39] |
| 7 | Annexin6 isoform (ANXA6) | A Ca2+ dependent membrane binding protein that regulates release of Ca2+ from intracellular stores | 0.57 | [40] |
| 8 | Neurogranin (NRGN) | A postsynaptic protein kinase C substrate which might play a role in regulation of long term potentiation and chemical synaptic transmission | 1.86 | [41], [42] |