Table 2.
List of synaptic SUMO target proteins identified among Pb2+ exposure and control groups.
| S. No. | Protein name | Function | References |
|---|---|---|---|
| 1 | Metabotropic glutamate receptor 3 (GRM3) | Modulates spontaneous epileptiform activity in the granule cells in DG region of hippocampus | [43] |
| 2 | Synapsin 3 (SYN3) | Plays role in regulation of neurotransmitter release and initial axon outgrowth | [44] |
| 3 | Lysosome-associated membrane glycoprotein 5 (LAMP5) | Tunes GABAergic synaptic transmission, thus affecting short term synaptic plasticity | [45] |
| 4 | Ionotropic glutamate receptor subtype NMDA 1 ((GluN1), GRIN1) | A subunit of NMDAR, provides a glycine binding site to the receptor | [46] |
| 5 | Double C2-like domain-containing protein alpha (Doc2-alpha, DOC2A) | Sensor of neurotransmission, helps in the regulation of neurotransmitter release | [47] |
| 6 | Flotillin-2 (FLOT2) | Regulates axonal regeneration and growth | [48] |
| 7 | Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2, GABBR2) | Essential for signal transduction by GABA-B receptors | [49] |
| 8 | Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2, SLC12A5) | A potassium-chloride co- transporter KCC2 encoded by SLC12A5, with fundamental roles in mediating fast synaptic inhibition by maintaining a hyperpolarizing gradient for chloride ions |
[50] |
| 9 | SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) | SRGAP2 co-regulates the density of spines and the length of the spine neck. | [51] |
| 10 | Tumor protein p63-regulated gene 1-like protein (TPRG1) | A vertebrate-specific presynaptic phosphoprotein interacting with Bassoon and synaptic vesicles (SVs) with unknown functions, also called Mover | [52] |