Table 5.
Key Pathway Advisor pathway predictions for agricultural chemicals and PPPs. Analysis based on the input of differentially expressed proteins (p = 0.05) induced by exposure of the DC model to the indicated substances against controls. In brackets: total number of pathways predicted. Proline: A closer look at the pathways could place one of them in category metabolism although KPA categorizes pathways under another header. * One pathway associated also to NF-KB signaling.
| Pathway associated with (total number of predicted pathways) | PRO (16) | Proline (2) | TEB (18) | Mix11 (10) | Folicur (6) | FLU (3) | Mix5 (1) | Mix6 (8) |
|---|---|---|---|---|---|---|---|---|
| Fatty acid, lipid, and cholesterol metabolism/homeostasis | – | – | – | 2 | – | – | – | – |
| TORC1 and TORC2 associated pathways | 1 | – | 2 | – | 1 | – | 2 | |
| Other metabolism | 1 | – | – | – | – | – | – | 1 |
| ER stress | – | – | – | – | – | – | – | |
| Chemotaxis/cell adhesion/cytoskeletal re-arrangements | – | – | 2 | – | – | – | – | – |
| Oxidative stress: ROS-induced cellular signaling | – | – | – | – | – | – | – | – |
| DNA damage | 3 | – | 2 | – | – | 1 | 1 | – |
| Other signal transduction | 2 | – | 2 | 3 | 1 | – | – | – |
| Numberof cytokine and immune response-associated pathways | 5 | – | 1 | 1 | 1 | – | – | 3 * |