Table 3.
Multivariable analysis of SF-12 scores associated with 0-I or III-IV acute graft-vs.-host disease
| SF-12 score | Parameter | Estimate | p-value |
|---|---|---|---|
| Physical subscale | Acute GVHD III-IV vs. 0-I | −4.37 | 0.02 |
| Myeloablative | 0.66 | 0.69 | |
| Donor match | 0.20 | ||
| Related | reference | ||
| Haploidentical | −19.29 | 0.07 | |
| Unrelated | −0.29 | 0.84 | |
| Donor female/patient male | −3.31 | 0.04 | |
| Donor/recipient CMV status | 0.74 | ||
| +/+ | reference | ||
| +/− | −1.22 | 0.49 | |
| −/+ | −0.86 | 0.72 | |
| −/− | −1.96 | 0.27 | |
| Year HCT | 0.53 | ||
| 2005–2009 | reference | ||
| 2010–2014 | −1.76 | 0.40 | |
| 2015–2019 | −0.24 | 0.91 | |
| Chronic GVHD | −2.23 | 0.12 | |
| Age at transplant, per year | −0.09 | 0.19 | |
| HCT-CI | 0.006 | ||
| 0 | reference | ||
| 1–2 | −1.65 | 0.36 | |
| 3+ | −5.47 | 0.002 | |
| Mental subscale | Acute GVHD III-IV vs. 0-I | −3.58 | 0.01 |
| Sex (male) | 0.80 | 0.47 | |
| Age at transplant, per year | 0.14 | 0.002 | |
| HCT-CI | 0.001 | ||
| 0 | reference | ||
| 1–2 | −3.50 | 0.01 | |
| 3+ | −4.91 | <0.001 |
SF-12, short form survey 12; GVHD, graft-versus-host disease; CMV, cytomegalovirus; HCT hematopoietic stem cell transplant; HCT-CI hematopoietic cell transplant-comorbidity index