Table 3.
Cord blood biomarkers level in neonatal sepsis.
| Clinical sepsis | |||||
|---|---|---|---|---|---|
| Hospital-Non sepsis (n = 248) | Hospital-sepsis (n = 167) |
p-value * | Suburban-Non sepsis (n = 161) | p-value** | |
| CD74 ¶ | 5.2 [3.1–7.1] | 4.7 [2–7.5] | 0.01 | 4.6 [3.2–7.2] | 0.03 |
| CX3CR1 ¶ | 0.8 [0.5–1.3] | 0.8 [0.4–1.5] | 0.31 | 1 [0.8–1.6] | 0.007 |
| IP-10 [pg/ml] | 76.8 [49–134.6] | 81.3 [56.9–143.1] | 0.51 | 105 [72.6–223] | < 0.001 |
| IL-10 [pg/ml] | 4.8 [2.9–8] | 5.3 [3–13.5] | 0.01 | 4.3 [2.9–10.2] | 0.05 |
| IL-6 [pg/ml] | 7.3 [2.7–118.5] | 29.9 [5.6–661.5] | < 0.001 | 23.1 [4.5–468.5] | 0.002 |
| PCT [pg/ml] | 458.3 [320.4–716.4] | 506.6 [358.5–987.3] | < 0.001 | 383 [225.7–543.7] | < 0.001 |
| Clinical Sepsis Adjudication | |||||
|---|---|---|---|---|---|
| Hospital-Non sepsis (n = 252) | Hospital-sepsis (n = 163) |
p-value* | Suburban-Non sepsis (n = 161) | p-value** | |
| CD74 ¶ | 5.3 [3.3–7.3] | 4.6 [1.8–6.8] | 0.01 | 4.6 [3.2–7.2] | 0.23 |
| CX3CR ¶1 | 0.8 [0.5–1.4] | 0.7 [0.4–1.3] | 0.37 | 1 [0.8–1.6] | 0.015 |
| IP-10 [pg/ml] | 79.5 [52.2–134.6] | 78.5 [49.8–142.8] | 0.51 | 105 [72.6–223] | < 0.001 |
| IL-10 [pg/ml] | 4.7 [2.8–7.7] | 5.5 [3.2–14] | 0.03 | 4.3 [2.9–10.2] | 0.30 |
| IL-6 [pg/ml] | 8.3 [2.8–124.7] | 26.8 [4.6–661.5] | < 0.001 | 23.1 [4.5–468.5] | < 0.001 |
| PCT [pg/ml] | 443.8 [304.3–670.2] | 583.5 [384.5–1022.7] | < 0.001 | 383 [225.7–543.7] | < 0.001 |
| Sepsis prognostic | |||||
|---|---|---|---|---|---|
| Survivors hospital (n = 368) | Non survivors hospital (n = 47) | p-value* | Suburban Survivors (n = 160) | p-value** | |
| CD74 ¶ | 5.3 [3.2–7.5] | 0.80 [0.3–3] | < 0.001 | 4.5 [3.2–7.18] | < 0.001 |
| CX3CR1 ¶ | 0.81 [0.4–1.4] | 0.70 [0.3–1.2] | 0.23 | 1 [0.7–1.59] | 0.12 |
| IP-10 [pg/ml] | 77.0 [52–132] | 87.0 [51.8–163.7] | 0.20 | 104.9 [70.8–214.4] | 0.73 |
| IL-10 [pg/ml] | 5.0 [3–9] | 5.7 [3.8–14.1] | 0.10 | 4.33 [2.94—10.2] | 0.10 |
| IL-6 [pg/ml] | 14.0 [4–213] | 147.0 [8.7–1034.2] | 0.002 | 26.71 [4.5–186.7] | 0.005 |
| PCT [pg/ml] | 463.0 [338–760] | 701.0 [424–1127] | 0.001 | 383.8 [227.8–557.5] | < 0.001 |
Biomarkers are expressed as median and inter-quartile range (IQR: Q1–Q3).
¶ CD74 and CX3CR1 are expressed as relative expression to HPRT1.
*Student’s t-test (or the Mann–Whitney t-test when distribution was not normal or Welch test when homoscedasticity was rejected) were performed to compare two hospital arms groups.
**Anova test was performed to compare biomarkers levels between the three groups.
p value was considered significant ≤ 0.05.
CD74, HLA class II histocompatibility antigen gamma chain; CX3CR1; CX3C chemokine receptor 1; IL, Interleukin; PCT, procalcitonin.