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. 2022 Dec 12;13:7675. doi: 10.1038/s41467-022-35225-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a The chemokine and cytokine levels in the eyes, including appendages, in SARS-CoV-2-infected mice, were measured using multiplex immuno-analysis (n = 4 per indicated dpi; 0 dpi, grey; 3 dpi, yellow; 6 dpi, red). G-CSF granulocyte-macrophage colony-stimulating factor, IP-10 C-X-C motif chemokine 10 (CXCL10), MKC mouse keratinocyte-derived chemokine, MCP-1 monocyte chemoattractant protein-1 (CCL2), MIP-2 macrophage-inflammatory protein-2 (CXCL2). b Photo of the visual cliff apparatus used in this study. c, d Time for latency to dismount platform (c) and the percentage of mice that took the first footstep over the cliff side (d) were measured (Mock, n = 9; SARS-CoV-2 (Normal), n = 7; SARS-CoV-2 (Ocular symptoms), n = 7). Symbols represent means ± SEM. Statistically significant differences between the groups were determined using one-way ANOVA (a, c). SARS-CoV-2 severe acute respiratory syndrome coronavirus 2, dpi days post-infection.