FIG. 1.

Hepatic phagocytic clearance (A), hepatic killing efficiency (B), and net hepatic killing (C) of E. coli. p47^phox−/− (wild-type) and p47^phox−/− (homozygous p47^phox-deficient) mice were pretreated with allopurinol or vehicle only, followed by intravenous E. coli challenge. Net hepatic killing and hepatic killing efficiency in p47^phox−/− were both modestly increased compared to those in wild-type mice (P < 0.05). Pretreatment with allopurinol had no significant effect on hepatic clearance or killing in either genotype. There were 8 or 9 mice per genotype per treatment group. Values are means ± standard deviations. Asterisks indicate P < 0.05.