Table 5. OCT findings in ISR lesions with and without calcified nodules.

		CN	Non-CN	p-value
Before the procedure		n=32	n=619
Distal reference lumen area, mm2		8.60±2.66	6.00±2.37	0.000
Proximal reference lumen area, mm2		9.65±2.73	7.39±2.34	0.000
Mean reference lumen area, mm2		9.12±2.47	6.70±2.21	0.000
At MLA site	Minimal lumen diameter, mm	1.66±0.47	1.32±0.50	0.000
	Minimal lumen area, mm2	2.30±1.11	1.43±0.74	0.000
	Stent diameter, mm	3.04±0.55	2.84±0.52	0.035
	Stent area, mm2	7.51±2.83	6.56±2.36	0.030
	Intimal area, mm2	5.21±2.41	5.14 ± 2.15	0.861
	Intimal area, %	68.6±13.6	77.0±10.8	0.000
	Stent expansion, %	81.9±17.5	99.4±22.4	0.000
At MSA site	Stent area, mm2	6.24±1.58	5.89±2.11	0.234
	Stent expansion, %	69.5±10.5	88.6±17.0	0.000
At CN site	Stent area, mm2	6.39±1.65
	Stent expansion, %	71.0±10.9
After the procedure		n=30	n=557
At MLA site	Minimal lumen diameter, mm	2.79±0.45	2.50±0.48	0.002
	Minimal lumen area, mm2	6.30±1.91	5.13±1.96	0.001
	Stent diameter, mm	3.41±0.53	3.20±0.51	0.032
	Stent area, mm2	9.39±2.82	8.28±2.61	0.024
	Intimal area, mm2	3.09±1.66	3.15±1.52	0.834
	Intimal area, %	31.8±14.8	38.1±13.0	0.010
	Initial gain, mm2	3.95±1.98	3.72±1.84	0.508
	ΔStent diameter, mm	0.35±0.36	0.36±0.27	0.870
	ΔStent area, mm2	1.78±2.14	1.70±1.36	0.750
	ΔIntimal area, mm2	2.17±2.17	2.03±1.63	0.641
	Stent expansion, %	103±18.8	126±24.7	0.000
At MSA site	Stent area, mm2	8.65±2.42	7.29±2.38	0.002
	Stent expansion, %	95.8±19.0	111±21.1	0.000
At CN site	Stent area, mm2	8.81±2.59
	Stent expansion, %	97.3±20.3
CN: calcified nodule(s); ISR: in-stent restenosis; MLA: minimum lumen area; MSA: minimum stent area; OCT: optical coherence tomography