Table 1. Number of Bioactive Thiazoles Containing Different Substituents Found in the ChEMBL Database.

	substituent position
substituent	2	4	5	total
any substituent	108 388			108 388
amide	22 179	550	466	23 195
amine (primary)	12 825 (4,062)	627 (479)	500 (396)	13 952 (4,937)
-COOR	31	473	1049	1553
-COOH	12	616	339	967
-Br	61	37	219	317
-CN	23	36	171	230