Table 2. Hit Rate for Each of the Assays Used to Evaluate a Focused Set of 49 Thiazoles and Thiadiazolesa.
| assay | no. of hits (hit rate) |
|---|---|
| MurA inhibition | 26 (53%) |
| 3CLpro inhibition | 14 (29%) |
| MetAP1a inhibition | 3 (6%) |
| DdlB inhibition | 0 (0%) |
| aqueous instability | 8 (16%) |
| HRP-PR redox activity | 0 (0%) |
| H2DCFDA redox activity | 2 (4%) |
| resazurin redox activity | 2 (4%) |
| DTNB thiol reactivity | 1 (2%) |
| TNB2– thiol reactivity | 19 (39%) |
a
Compounds with spectral interference were classified as false positives and excluded from the hits.