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. 2022 Nov 10;13(12):1856–1863. doi: 10.1021/acsmedchemlett.2c00213

Figure 3.

Figure 3

Lazertinib bound to inactive EGFR(T790M/V948R) with distinct conformations. (A) Lazertinib bound with phenyl ring anchored within van der Waals distance to the T790M methionine (∼3.8 Å) and methane amine involved in intramolecular H-bonding. (B) A “flipped” conformation with outward phenyl and methyleneamine donating an H-bond to D855. Other interactions seen in this structure include an intramolecular dipole–dipole pyrazole to carbonyl (3.2 Å) as well as a van der Waals methyleneamine methyl to thioether (3.8 Å). P-loop cartoon removed for clarity. (PDB ID 7UKW).