Table 2. Antiproliferative Activities on the Proliferation of Ba/F3 Cell Lines of EGFR(L858R), EGFR(L858R/T790M), and Wild-Type HER2a.
| Cellular
(Ba/F3) antiproliferative activity EC50 (nM) |
|||
|---|---|---|---|
| Compound | EGFR(L858R) | EGFR(L858R/T790M) | WT HER2 |
| Lazertinib | 4.8 ± 2 | 7.4 ± 1 | >100 |
| Osimertinib | 3.2 ± 0.3 | 14 ± 4 | 34 ± 8 |
| LN2057 | 0.51 ± 0.08 | 21 ± 5 | 2.7 ± 1 |
a
EC50 values are averages of at least three independent experiments with each experiment performed in triplicate. Errors are reported as ± standard deviation.