Table 5. Experimental ADME Parameters for Selected Key Compounds.

#	solubility [μM in PBS]	log D	metabolic stability (mouse liver S9 fraction) t1/2, [min]
58	11	3.77	2.3
63	84	3.32	1.1
74	119	2.93	0.9
83	19	3.46	1.9
89	14	3.93	0.8
91	36	3.52	2.0
92	23	3.82	0.7
94	294	2.79	3.0
98	55	3.53	0.8
101	13	3.42	0.8