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| IC50 (μM)a |
|||
|---|---|---|---|
| compd | Hsp90α | Hsp90β | fold selectivity |
| 3 | 0.51 ± 0.01 | 5.10 ± 0.11 | ∼10 |
| 4 | 2.74 ± 0.20 | 14.91 ± 0.11 | ∼5 |
| 5 | >50 | >50 | NSb |
| 6 | >50 | >50 | NS |
| 7 | 36.00 ± 1.56 | >50 | >1 |
IC50 values are reported as the mean of triplicates ± SD.
NS = nonselective.
