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. 2022 Nov 4;13(12):1870–1878. doi: 10.1021/acsmedchemlett.2c00327

Table 2. Binding Affinities and Selectivities for Hsp90α > Hsp90β Obtained by FP Assay.

  IC50 (μM)a
  
compd Hsp90α Hsp90β fold selectivity
11 37.87 ± 1.24 >50 >1
14 6.15 ± 0.76 >50 >8
16 0.478 ± 0.010 5.23 ± 0.02 ∼11
18 36.00 ± 1.56 >50 >1
a

IC50 values are reported as the mean of triplicates ± SD.