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. 2022 Nov 4;13(12):1870–1878. doi: 10.1021/acsmedchemlett.2c00327

Table 4. Binding Affinities and Selectivities for Hsp90α > Hsp90β Obtained by FP Assaya.

    IC50 (μM)
  
compd n Hsp90α Hsp90β fold selectivity
23a 0 3.87 ± 0.32 39.32 ± 2.64 ∼10
23b 1 3.84 ± 0.31 >50 >13
23c 2 3.03 ± 0.19 >50 >13
23d 3 0.25 ± 0.01 3.67 ± 0.14 ∼15
23e 4 0.33 ± 0.87 4.28 ± 0.07 ∼13
KUNA-111 3 0.25 ± 0.01 3.79 ± 0.18 ∼15
a

IC50 values are reported as the mean of triplicates ± SD.