Table 2.
Relative antigenotoxic effect of ВР-С2 against DNA damage induced by DN in tissues of BALB/c mice in vivo (%).
| Tissue | DN, 300 mg/kg | DN, 300 mg/kg + ВР-С2, 60 mg/kg | DN, 300 mg/kg + ВР-С2, 80 mg/kg | DN, 300 mg/kg + ВР-С2, 120 mg/kg |
|---|---|---|---|---|
| A. Alkaline comet Assay | ||||
| Bone marrow | 100 | 57 (–43) | 80 (–20) | 65 (–35) |
| Liver | 100 | 64 (–36) | 59 (–41) | 86 (–14) |
| Blood cells | 100 | 71 (–29) | 55 (–45) | 47 (–53) |
| B. Neutral comet Assay | ||||
| Bone marrow | 100 | 59 (–41) | 51 (–49) | 68 (–32) |
| Liver | 100 | 66 (–34) | 39 (–61) | 73 (–27) |
| Blood cells | 100 | 42 (–58) | 50 (–50) | 74 (–26) |
DN – dioxidine. Numbers in parentheses indicate relative difference from the positive control taken as 100%.