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. 2022 Dec 12;21:215. doi: 10.1186/s12943-022-01687-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Evaluation of OPN expression in human DLBCL samples and cell lines. A. Representative IHC for OPN performed on human lymphoma biopsies. Scale bar: 100 μm (left) and 50 μm (right). B. Quantification of OPN expression on GC- vs ABC-DLBCL samples (Student t test; **, p: 0.0036). Six cases were analyzed for each subtype. Quantification was performed analysing 5 areas/sample by using Positive Pixel count v9 Leica Software Image Analysis algorithm. C. Boxplots showing the expression of SPP1 (Student t test; *** p: 0.0009), PRDM1 (Student t test, **, p: 0.0047) and STAT3 (Student t test, ****, p: 4.863E-14) in ABC- VS GCB-DLBCL samples in GSE4475. Dots in boxplot represent the expression of the selected gene in each sample. D. Immunofluorescence on cytospin preparation showing OPN expression in SU-DHL-4 and SU-DHL-10 (GC-DLBCL-s), TMD8 and U2932 (ABC-DLBCL) cell lines. Scale bar: 30 μm (upper panels) and 10 μm (lower panel)