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. 2022 Dec 12;20:583. doi: 10.1186/s12967-022-03779-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — C/EBPβ knockdown inhibited the overexpression of Clec7a and NLRP3 induced pyroptosis in spinal cord of the chronic constriction injury rats. A The double immunofluorescence staining of C/EBPβ and Clec7a in ipsilateral SC of CCI rats after si-Cebpb administration (n = 6 rats/group, 1 section/rat). White arrows point to C/EBPβ- and Clec7a-positive cells. Scale bar: 50 μm. B Representative images (left) and quantification evaluation (right) of Tunel staining in the indicated groups (n = 6 rats/group, 1 section/rat). Red: Tunel-positive cells; blue: nuclei (Hoechst 33,258). Scale bar: 100 μm. Data are presented as mean ± SEM. One-way ANOVA was used to analyze data among multiple groups followed by Tukey’s post hoc test for equal variances or Dunnett T3 post hoc test for unequal variances. ^*P < 0.05, ^**P < 0.01 compared with the Sham group; ^##P < 0.01 compared with sham + si-NC group; ^△P < 0.05, ^△△P < 0.01 compared with CCI + si-NC group