Table 4.

Comparison of characteristics and hematologic and inflammatory parameters between Groups I + II + III and IV

Group	I + II + III (n = 258)	IV (n = 13)	P value
Age (years)	61 [41, 74]	73 [41, 75]	0.298
Sex (male)	133 (51.6%)	5 (38.5%)	0.405
Body mass index	22.4 [20.2, 25.0]	21.3 [18.7, 23.4]	0.345
Cause			0.672
Lesion			0.571
Maxilla	53 (20.5%)	1 (7.7%)
Mandible	200 (77.5%)	12 (92.3%)
Others†	5 (1.9%)	0
Location of odontogenic cause			0.565
Anterior	32 (12.4%)	1 (7.7%)
Premolar	20 (7.8%)	0
Molar	180 (69.8%)	12 (92.3%)
Others‡	26 (10.1%)	0
Compromised host§	63 (24.4%)	7 (53.8%)	0.044*
Fever (°C)	37.2 [36.6, 37.7]	37.4 [36.9, 37.8]	0.207
Blood test data
Albumin (g/dl)	3.6 [3.3, 4.0]	2.7 [2.4, 3.0]	< 0.001*
C-reactive protein (mg/dl)	9.1 [5.7, 13.9]	23.9 [21.0, 32.3]	< 0.001*
White blood cell (× 103/µl)	12.1 [9.7, 14.7]	19.0 [14.7, 21.0]	< 0.001*
Neutrophil (%)	80.8 [74.7, 85.4]	91.5 [89.4, 93.4]	< 0.001*
Lymphocyte (%)	12.0 [8.1, 17.0]	3.9 [2.4, 6.0]	< 0.001*
Platelet (× 104/µl)	26.2 [21.1, 31.5]	33.1 [18.0, 36.6]	0.382
Hemoglobin (g/dl)	13.4 [12.3, 14.6]	11.9 [10.7, 13.1]	0.027*
Sodium (mmol/L)	139 [137, 140]	136 [133, 140]	0.064
Creatinine (mg/dl)	0.76 [0.62, 0.94]	0.98 [0.77, 1.59]	0.035*
Glucose (mg/dl)	115 [100, 133]	112 [96, 138]	0.988
LRINEC score	1 [1, 4]	7 [6, 8]	< 0.001*
NLR	6.7 [4.4, 10.3]	23.3 [15.3, 38.9]	< 0.001*
PLR	179.8 [134.3, 265.3]	301.9 [235.5, 662.4]	0.006*
SII	173.7 [110.2, 292.3]	706.3 [494.7, 925.7]	< 0.001*
CRP + NLR	16.3 [12.0, 23.8]	51.0 [35.1, 60.8]	< 0.001*

Data are shown as the median [first quartile, third quartile]

^*Statistically significant (P < 0.05)

LRINEC laboratory risk indicator for necrotizing fasciitis, NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; SII, systemic immune-inflammation index

^†Buccal; tongue

^‡Maxillary sinus; salivary gland; lip

^§Diabetes mellitus; corticosteroids usage; hemodialysis