Table 5.
Comparison of hematologic and inflammatory parameters as predictive tests for necrotizing soft tissue infection
| Cut-off value | AUC | 95% CI | Sensitivity (%) | Specificity | PPV | NPV (%) | LR + | LR- | |
|---|---|---|---|---|---|---|---|---|---|
| CRP (mg/dl) | 20.9 | 0.894 | 0.771–1.000 | 84.6 | 93.0% | 37.9% | 99.2 | 12.1 | 0.17 |
| WBC (× 103/µl) | 17.5 | 0.857 | 0.754–0.961 | 69.2 | 91.1% | 28.1% | 98.3 | 7.76 | 0.33 |
| LRINEC score | 6 | 0.941 | 0.890–0.992 | 92.3 | 90.3% | 32.4% | 99.6 | 9.53 | 0.09 |
| NLR | 14.2 | 0.901 | 0.817–0.985 | 92.3 | 86.8% | 26.1% | 99.6 | 7.00 | 0.09 |
| PLR | 229 | 0.758 | 0.605–0.911 | 84.6 | 65.5% | 11.0% | 98.8 | 2.45 | 0.23 |
| SII | 495 | 0.870 | 0.754–0.986 | 76.9 | 89.5% | 27.0% | 98.7 | 7.35 | 0.26 |
| CRP + NLR | 27 | 0.947 | 0.910–0.948 | 100 | 82.6% | 22.4% | 100 | 5.73 | 0 |
CRP C-reactive protein, WBC white blood cell, LRINEC laboratory risk indicator for necrotizing fasciitis, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, SII systemic immune-inflammation index, AUC area under the curve, CI confidence interval, PPV positive predictive value, NPV negative predictive value, LR + positive likelihood ratio, LR− negative likelihood ratio