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. 2022 Dec 12;222:113090. doi: 10.1016/j.colsurfb.2022.113090

Fig. 1.

Fig. 1

Cholesterol-recognition motifs in the TM region of spike S glycoprotein from SARS-CoV-2, SARS-CoV, and MERS-CoV. A) Sequences of the cholesterol-recognition motifs. B) Schematic diagram of SARS-CoV-2 primary structure. SS, signal sequence; NTD, N-terminal domain; RBD, receptor binding domain; FP, fusion peptide; HR1, heptad repeat 1; CH, central helix; CD, connector domain; HR2, heptad repeat 2; TM, transmembrane domain; CT, cytoplasmic tail. C) Cholesterol-recognition motifs along the linear sequences of the TMs. The TM region exhibits back-to-back mirror images of highly conserved CRAC (green) and CARC (red) motifs at the N-term juxtamembrane aromatic region.