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Top view of SARS-CoV-2, and Omicron BA.1 spike protein. CRAC and CARC motifs are colored green and red, respectively. The approximate position of the sequences SARS-CoV-2 444–461, and Omicron BA.1 441–458 are highlighted by a dotted light-blue circle. Letters highlighted in yellow correspond to plasma membrane-interacting residues proposed by Overduin et al. [43].
