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Model for the interactions between bacterial membranes, lipid transfer proteins, and mCD14-expressing cells in human plasma. LBP can transfer LPS from blebs to HDL, mCD14-expressing cells, or sCD14. sCD14 may transfer LPS from blebs to mCD14-expressing cells or HDL, and it can also transfer LPS from mCD14-expressing cells to lipoproteins. Although PLTP can transfer LPS from blebs to isolated HDL particles, a role in LPS transfer to lipoproteins in complete serum could not be shown.
