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. 2022 Jul 26;25(12):979–991. doi: 10.1093/ijnp/pyac043

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© The Author(s) 2022. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Dose-dependent effect of zelquistinel on metaplasticity in the hippocampus. Long-lasting enhancement of LTP (metaplasticity) in rat hippocampal slices at 24 hours post dose was produced by a single oral dose of zelquistinel. (A) Time course of induction of metaplasticity by zelquistinel (10 µg/kg to 10 mg/kg, PO). (B) Dose-dependent effect of a single oral dose of zelquistinel; the magnitude of LTP, induced 24 hours post dose, is presented as normalized fEPSP slopes after the third and final set of theta burst stimuli, representing maximal LTP at Schaffer collateral-CA1 synapses. *P < .05 vs no-drug control slices via ANOVA followed by Dunnett’s post hoc test comparing each dose to vehicle (n = 10 for each dose tested).