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. 2022 Jul 26;25(12):979–991. doi: 10.1093/ijnp/pyac043

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© The Author(s) 2022. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Zelquistinel dose-dependently produced and long-lasting antidepressant-like response. (A) Zelquistinel produced dose-dependent rapid antidepressant-like responses in the rat forced swim test 60 minutes post dose (n = 10 rats for each dose). *P < .05, ***P < .001 vs vehicle via 1-way ANOVA followed by Dunnett´s multiple comparison test. (B) Zelquistinel produces an acute and long-lasting antidepressant-like response with most effective dose of 30 μg/kg (n = 9–10 rats for each dose). *P < .05, **P < .01, ***P < .001 vs vehicle via 1-way ANOVA followed by Dunnett´s multiple comparison test.