TABLE 3.

Antibiotic Selection and Schedule in Irradiated Animal Models

Mouse	Rat	Rabbit	Minipig	NHP
Acidified, autoclaved water	Enrofloxacin (~10 mg/kg/day) in drinking water from day 2 to 14	Bactrim (sulfamethoxazole/trimethoprim, 30 mg/kg) once daily from day 3 to 30	Amoxicillin (10 mg/kg, PO, BID from day 3 to 30), flavored tablet	Full supportive care model: Trigger to treat adapted from UMSOM
Ciprofloxacin in water - common prophylactic regimen in mice (UIC)			Gentamicin (2 mg/kg, PO, daily from Day 3 to 30)	Minimal supportive care model: Enrofloxacin, 10 mg/kg, PO or IM
Antibiotics in water no improvement in survival (UIC)