TABLE 5.

Infection Control Procedures in Irradiated Animal Models, Survey Findings by Participating Subject Matter Experts

Mouse	Rat	Rabbit	Minipig	NHP
Housed in microisolator cages and single housed	Housed in microisolator cages	Cages changed twice weekly	Cages rotated daily	Separate treatment room for blood collection and treatments
Autoclaved, acidified water	All cage components sterilized before use	Cages sanitized and surveyed with RODAC plates then wrapped in plastic until use	Cages completely sanitized between use and surveyed with RODAC plates	All tables where animals are placed are disinfected between animals
	Cages changed weekly	High touch surfaces cleaned with disinfectant daily	Minipigs trained for targeting to move around room	Room entry guidelines and restrictions
	Reverse osmosis, hyperchlorinated water	Restrainers cleaned between animals	Neutropenic animals housed in separate room	Twice weekly cage sanitization with RODAC survey
	Room entry order and guidelines followed, including PPE	Neutropenic animals housed in separate room	All animals isolated from colony from arrival until termination
			Fresh bedding for sick animals