TABLE 6.

Hydration and Diet for TBI and PBI Animal Models

	Mouse	Rabbit	Minipig	Non-human primate
Adequate feeding	TBI/PBI: Gel packs due to anticipated tooth decay/loss	Fruits and vegetables	Fruits and vegetables	Fruits, vegetables, high-protein diet in MCT oil for ≥10% BW loss
	WTLI: standard chow only			Citrus (acidity) is avoided
Adequate hydration	TBI/PBI: Hyperchlorinated H2O (10 ppm); Hydropac system	Treated water via self-watering system (in-cage lixit)
	Gel packs include large H2O component	Pedialyte, fruit juice or water may be provided
	WTLI: Hyperchlorinated H2O	Trigger to treat hydration: fluids provided IV or oral gavage based on dehydration Less dehydration in rabbits/minipigs
Best route of administration	Oral, SC, IV or OG	Multiple routes depending on severity of dehydration