TABLE 7.
Comparison of Euthanasia Criteria in Animal Models Across Subset of Representative Institutes
| Large animal |
Small animal |
|||||
|---|---|---|---|---|---|---|
| LBRI (NHP/swine) |
CRL (NHP/Swine) |
UMSOM (NHP) |
AFRRI (Mice) |
MCW (Rat) |
UMSOM (Rabbits) |
|
| Excessive bleeding | X | X | X | X | ||
| Severe dehydration | X | X | X | X | ||
| Respiratory distress | X | X | X | X | X | X |
| Body weight loss | X | X | X | X | X | |
| Decreased food/water | X | X | ||||
| Lethargy/weakness | X | X | X | X | X | X |
| Seizure activity | X | X | X | X | ||
| Loose bloody stool | X | X | ||||
| Paina | X | X | X | |||
| Self-mutilation | X | |||||
| Rectal temperature ≥106°F (41.1°C) or <96°F (35.6°C) for >6 h | X | |||||
a
Animals in pain receive analgesics, and unrelenting pain in the face of analgesic treatment would be a de facto euthanasia criterion.
Abbreviations. Lovelace Biomedical Research Institute (LBRI); Charles River Laval (CRL); University of Maryland School of Medicine (UMSOM); Armed Forces Radiobiology Research Institute (AFRRI); Medical College of Wisconsin (MCW).