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. Author manuscript; available in PMC: 2022 Dec 12.
Published in final edited form as: J Am Coll Cardiol. 2015 Feb 10;65(5):512–514. doi: 10.1016/j.jacc.2014.08.057

Figure 1.

Figure 1.

TGFβR1 Inhibition Reduces TEVG Stenosis by Blocking EndoMT

(A) Tie2 and Cdh5 models with lineage tracing images in occluded TEVG. Arrows show co-localized cells (left). Quantification demonstrating that EndoMT significantly contributes to TEVG stenosis in both models (right, *p < 0.05, **p < 0.01). (B) SB431542 treatment in the Tie2 lineage tracing model significantly reduces the occurrence of EndoMT in occluded TEVG. Arrows show co-localized cells (*p < 0.05). DMSO = dimethyl sulfoxide; SMA = smooth muscle actin.